Efficacy of tripterygium glycosides on experimental autoimmune myasthenia gravis in rats
نویسندگان
چکیده
This study aimed to explore the therapeutic efficacy of tripterygium glycosides for experimental autoimmune myasthenia gravis (EAMG). EAMG model was established in rats, and the rats were divided into complete Freund’s adjuvant group, EAMG model group and tripterygium glycosides treatment group. All rats were evaluated by Lennon scoring and body mass monitoring. We found that the treatment with tripterygium glycosides improved the clinical symptoms of myasthenia gravis, reduced Lennon score but increased body mass. Furthermore, tripterygium glycosides effectively reduced the activities of specificity-activated antigen-reactive T cells and the expression and secretion of pro-inflammatory cytokines such as IL-17 and IFN-γ. In conclusion, tripterygium glycosides are a promising agent for the treatment of autoimmune myasthenia gravis.
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